Real-world Evidence of COVID-19 Vaccines Effectiveness in Solid-organ Transplant Recipient Population in Colombia: A Study Nested in the Esperanza Cohort.

BACKGROUND: Solid-organ transplant recipients (SOTRs) have a higher risk of coronavirus disease 2019 (COVID-19) complications and death and a less powerful and lasting response to vaccines and to natural infection. In Colombia, this population was prioritized in the National Vaccination Plan against COVID-19 and received vaccines from different platforms. The aim of this study was to estimate the effectiveness of the complete vaccination schedule and of the vaccine booster for COVID-19 administered to SOTRs in Colombia. METHODS: A nested-cohort was assembled within the population-based ESPERANZA cohort and included the subset of 16 y and older SOTRs (n = 6963); the follow-up period spanned March 11, 2021, to May 11, 2022. The vaccine effectiveness was estimated with Cox proportional-hazards models so that the overall effectiveness of the complete vaccination schedule, the vaccine booster, each used vaccine, and the homologous and heterologous schedules were estimated, adjusting by the main confounders. RESULTS: The overall effectiveness of being fully vaccinated was 73.7% (95% confidence interval [CI], 68.9%-77.0%) to prevent COVID-19 infection, 83.7% (95% CI, 78.7%-87.5%) to prevent hospitalization, and 92.1% (95% CI, 88.8%-94.4%) to prevent death due to COVID-19. Similarly, the effectiveness of the vaccine booster was 76.7% (95% CI, 70.6%-81.5%), 86.9% (95% CI, 79.4%-91.6%), and 94.5% (95% CI, 89.8%-97.1%) to prevent confirmed COVID-19 infection, hospitalization, and death due to COVID-19, respectively. In both cases, there were no statistically significant differences across age groups. CONCLUSIONS: Findings from this work show a high protection of vaccination against infection, hospitalization, and death due to COVID-19 in SOTRs, which increases with the vaccine booster.

Determinantes del peso al nacer en hijos de mujeres venezolanas migrantes irregulares en Barranquilla y Riohacha / Determinants of birth weight among children of irregular migrant Venezuelan women in Barranquilla and Riohacha

RESUMEN Objetivo Describir los factores determinantes del peso al nacer en los hijos de mujeres venezolanas en condición migratoria irregular durante la gestación, en Barranquilla y Riohacha, en el periodo 2018-2019. Materiales y Métodos Se realizó un estudio descriptivo longitudinal de fuente secundaria, con base hospitalaria y comunitaria. Se incluyeron los binomios madre-hijo de mujeres venezolanas en condición irregular cuyo parto se presentó en Barranquilla y Riohacha entre julio de 2018 y diciembre de 2019 (n=563). Resultados Se encontró asociación estadísticamente significativa entre el número de controles prenatales y el bajo peso al nacer. Las odds de nacer con bajo peso entre quienes no tuvieron controles fueron de 4,0 veces en relación con quienes cumplieron con al menos 4 controles durante el embarazo (OR=4,0; IC 95% 1,5 - 10,4). Conclusiones Se encontró que la probabilidad de bajo peso al nacer en los recién nacidos de aquellas madres que no se realizaron controles prenatales es superior en un 82,7% a la de los hijos de las madres que tuvieron cuatro controles prenatales o más.(AU)

ABSTRACT Objective To describe the determinants of birth weight in the children of Venezuelan women in irregular migration status during pregnancy, in Barranquilla and Riohacha, between 2018 and 2019. Materials and Methods We carried out a longitudinal and descriptive study of secondary source, with a hospital and community basis. We included mother-child pairs of Venezuelan women in an irregular condition whose delivery occurred in Barranquilla and Riohacha between July 2018 and December 2019 (n=563). Results: We found a significative association between the number of prenatal care and low birth weight. The odds of being born with low birth weight among those who had no controls was 4.0 times in relation to those who met at least 4 controls during pregnancy (OR = 4.0, 95% CI 1.5 - 10.4). Conclusions The probability of low birth weight in the newborns of those mothers who did not have prenatal controls was 82.7% higher compared to the children of mothers who had four or more prenatal cares.(AU)

Desigualdades sociales en la mortalidad de niños menores de cinco años: revisión sistemática / Social inequalities in under-five mortality: a systematic review

RESUMEN Objetivo Identificar las características de los estudios sobre desigualdades sociales, en la mortalidad de niños menores de cinco años; sus perspectivas teóricas, ejes de desigualdad, métodos y resultados. Método Revisión sistemática de la literatura. Se consultaron cuatro bases de datos electrónicas y Google Scholar; se incluyeron estudios entre 2010 y 2018. Resultados Se analizaron 126 artículos. En el 62,7%, se estudió el territorio como eje de desigualdad, seguido por los determinantes socioeconómicos (27,8%). La mortalidad neonatal, infantil y en la niñez fue analizada en el 19,0%, 49,2% y 32,3%, respectivamente. Predominaron los estudios ecológicos (62,7%) y longitudinales (50,0%). Se encontró una disminución considerable en las tasas de mortalidad; sin embargo, el descenso no fue homogéneo entre subpoblaciones. Conclusiones La literatura reporta una marcada disminución de la mortalidad en niños menores de cinco años; no obstante, las brechas entre distintos ejes de desigualdad continúan y en algunos lugares se han incrementado. Las brechas entre los estratificadores variaron de acuerdo con el tiempo, lugar, eje de desigualdad y tipo de mortalidad analizada.(AU)

ABSTRACT Objective To identify the characteristics of the published studies on social inequalities in under-five mortality, their theoretical perspectives, axes of inequality, methods and results. Method We carried out a systematic literature review. We consulted four electronic databases and Google Scholar, for studies published between 2010 and 2018. Results We analyzed 126 articles. In 62.7%, territory was studied as the axis of inequality, followed by socioeconomic determinants (27.8%). Neonatal, infant and under-five mortality was analyzed as an output in health in 19.0%, 49.2% and 32.3%, respectively. It predominated ecological (62.7%) and longitudinal (50.0%) studies. Significant reductions in mortality rates were found, however, the decline was not homogeneous among subpopulations. Conclusions The literature reports a marked decrease in under-five mortality; however, the gaps between different axes of inequality continue and in some cases they have increased. Gaps varied according to time, place, axis of inequality and type of mortality analyzed.(AU)

[Social inequalities in under-five mortality: a systematic review]. / Desigualdades sociales en la mortalidad de niños menores de cinco años: revisión sistemática.

OBJECTIVE: To identify the characteristics of the published studies on social inequalities in under-five mortality, their theoretical perspectives, axes of inequality, methods and results. METHOD: We carried out a systematic literature review. We consulted four electronic databases and Google Scholar, for studies published between 2010 and 2018. RESULTS: We analyzed 126 articles. In 62.7%, territory was studied as the axis of inequality, followed by socioeconomic determinants (27.8%). Neonatal, infant and under-five mortality was analyzed as an output in health in 19.0%, 49.2% and 32.3%, respectively. It predominated ecological (62.7%) and longitudinal (50.0%) studies. Significant reductions in mortality rates were found, however, the decline was not homogeneous among subpopulations. CONCLUSIONS: The literature reports a marked decrease in under-five mortality; however, the gaps between different axes of inequality continue and in some cases they have increased. Gaps varied according to time, place, axis of inequality and type of mortality analyzed.

[Determinants of birth weight among children of irregular migrant Venezuelan women in Barranquilla and Riohacha]. / Determinantes del peso al nacer en hijos de mujeres venezolanas migrantes irregulares en Barranquilla y Riohacha.

OBJECTIVE: To describe the determinants of birth weight in the children of Venezuelan women in irregular migration status during pregnancy, in Barranquilla and Riohacha, between 2018 and 2019. MATERIALS AND METHODS: We carried out a longitudinal and descriptive study of secondary source, with a hospital and community basis. We included mother-child pairs of Venezuelan women in an irregular condition whose delivery occurred in Barranquilla and Riohacha between July 2018 and December 2019 (n=563). Results: We found a significative association between the number of prenatal care and low birth weight. The odds of being born with low birth weight among those who had no controls was 4.0 times in relation to those who met at least 4 controls during pregnancy (OR = 4.0, 95% CI 1.5 - 10.4). CONCLUSIONS: The probability of low birth weight in the newborns of those mothers who did not have prenatal controls was 82.7% higher compared to the children of mothers who had four or more prenatal cares.

OBJETIVO: Describir los factores determinantes del peso al nacer en los hijos de mujeres venezolanas en condición migratoria irregular durante la gestación, en Barranquilla y Riohacha, en el periodo 2018-2019. MATERIALES Y MÉTODOS: Se realizó un estudio descriptivo longitudinal de fuente secundaria, con base hospitalaria y comunitaria. Se incluyeron los binomios madre-hijo de mujeres venezolanas en condición irregular cuyo parto se presentó en Barranquilla y Riohacha entre julio de 2018 y diciembre de 2019 (n=563). RESULTADOS: Se encontró asociación estadísticamente significativa entre el número de controles prenatales y el bajo peso al nacer. Las odds de nacer con bajo peso entre quienes no tuvieron controles fueron de 4,0 veces en relación con quienes cumplieron con al menos 4 controles durante el embarazo (OR=4,0; IC 95% 1,5 - 10,4). CONCLUSIONES: Se encontró que la probabilidad de bajo peso al nacer en los recién nacidos de aquellas madres que no se realizaron controles prenatales es superior en un 82,7% a la de los hijos de las madres que tuvieron cuatro controles prenatales o más.

Modos de vida y estado de salud de migrantes en un asentamiento de Barranquilla, 2018 / Lifestyles and health status of migrants in a settlement of Barranquilla, Colombia, 2018

RESUMEN Objetivo Describir los modos de vida y el estado de salud de salud de migrantes venezolanos y colombianos de retorno asentados en Villa Caracas, Barranquilla, en el año 2018. Método Estudio descriptivo de corte transversal con muestreo sistemático de viviendas. Fueron incluidas 229 personas mayores de 15 años procedentes de 90 viviendas. Resultados Se encontraron diferencias en las rutas para llegar, tiempos de traslado y estancia en el asentamiento entre migrantes venezolanos y colombianos en retorno. Las condiciones de la vivienda y el acceso a los servicios públicos son limitadas, menos de la mitad de las viviendas tienen acceso a acueducto, alcantarillado y baño. En general el estado de salud auto-reportado por los migrantes es muy bueno o bueno, las prevalencias de enfermedades crónicas fueron relativamente bajas, con excepción de hipertensión arterial. De los que consultaron al servicio de urgencias, la mayoría reportó acceso efectivo. Se encontraron síntomas depresivos clínicamente significativos para el 20% de la población encuestada. Conclusiones Los migrantes de Villa Caracas se encuentran en condiciones de alta vulnerabilidad social dadas sus condiciones económicas y ambientales. A pesar de la falta de aseguramiento al sistema de salud colombiano, reportaron acceso a la atención por urgencias.(AU)

ABSTRACT Objective To describe the lifestyles and health status of returning Venezuelan and Colombian migrants in Villa Caracas, Barranquilla, in 2018. Methods Descriptive, cross-sectional study with systematic sampling of dwellings. 229 people over 15 years of age from 90 homes were included. Results Differences were found in the routes to arrive, commuting times and stay in the settlement between Venezuelan and returning Colombian migrants. Housing conditions and access to public services are limited: less than half of the dwellings have access to aqueduct, sewerage and bathrooms. In general, self-reported health status of migrants is very good or good and the prevalence of noncommunicable diseases was relatively low, with the exception of high blood pressure. Most of the people who consulted the emergency department reported effective access. Clinically significant depressive symptoms were found in 20% of the surveyed population. Conclusions The migrants of Villa Caracas are under high social vulnerability conditions given their economic and environmental conditions. Despite their lack of enrollment in the Colombian health system, they reported access to emergency care.(AU)

[Lifestyles and health status of migrants in a settlement of Barranquilla, Colombia, 2018]. / Modos de vida y estado de salud de migrantes en un asentamiento de Barranquilla, 2018.

OBJECTIVE: To describe the lifestyles and health status of returning Venezuelan and Colombian migrants in Villa Caracas, Barranquilla, in 2018. METHODS: Descriptive, cross-sectional study with systematic sampling of dwellings. 229 people over 15 years of age from 90 homes were included. RESULTS: Differences were found in the routes to arrive, commuting times and stay in the settlement between Venezuelan and returning Colombian migrants. Housing conditions and access to public services are limited: less than half of the dwellings have access to aqueduct, sewerage and bathrooms. In general, self-reported health status of migrants is very good or good and the prevalence of noncommunicable diseases was relatively low, with the exception of high blood pressure. Most of the people who consulted the emergency department reported effective access. Clinically significant depressive symptoms were found in 20% of the surveyed population. CONCLUSIONS: The migrants of Villa Caracas are under high social vulnerability conditions given their economic and environmental conditions. Despite their lack of enrollment in the Colombian health system, they reported access to emergency care.

OBJETIVO: Describir los modos de vida y el estado de salud de salud de migrantes venezolanos y colombianos de retorno asentados en Villa Caracas, Barranquilla, en el año 2018. MÉTODO: Estudio descriptivo de corte transversal con muestreo sistemático de viviendas. Fueron incluidas 229 personas mayores de 15 años procedentes de 90 viviendas. RESULTADOS: Se encontraron diferencias en las rutas para llegar, tiempos de traslado y estancia en el asentamiento entre migrantes venezolanos y colombianos en retorno. Las condiciones de la vivienda y el acceso a los servicios públicos son limitadas, menos de la mitad de las viviendas tienen acceso a acueducto, alcantarillado y baño. En general el estado de salud auto-reportado por los migrantes es muy bueno o bueno, las prevalencias de enfermedades crónicas fueron relativamente bajas, con excepción de hipertensión arterial. De los que consultaron al servicio de urgencias, la mayoría reportó acceso efectivo. Se encontraron síntomas depresivos clínicamente significativos para el 20% de la población encuestada. CONCLUSIONES: Los migrantes de Villa Caracas se encuentran en condiciones de alta vulnerabilidad social dadas sus condiciones económicas y ambientales. A pesar de la falta de aseguramiento al sistema de salud colombiano, reportaron acceso a la atención por urgencias.